The Hotel Subasio is adjacent to the Basilica of St. Francis, connected via an arched colonnade. It is 500 meters to the Rocca Maggiore Castle and 700 meters to the Temple of Minerva. The Hotel Subasio is 4 km from the train station.

The 61 rooms at the Hotel Subasio are available in 19th century décor or modern styles. There are eight suite style rooms as well. Rooms include Internet access, television, telephone, minibar, safe box, and en suite bathrooms with hair dryers. Balconies are also standard on each room.

The Hotel Subasio is a four star hotel that was completely renovated in 2008. It has four levels, with include three restaurants, a bar, and a coffee shop. A complimentary buffet breakfast is served each morning. Conference space is also available for business meetings or social banquets. Terraces on the lower level provide lounge space. There is a large parking lot for guests. Smoking areas are designated.